Ramkumar Mathur

1. Celik H, Bansal B, Gill JS, Correa JK, Herman K, Goyal R, Çelik V, Guo K, Mathur R*. Age-stratified analysis of therapeutic, immune, and glycosylation gene expression in colorectal cancer using machine learning. Sci Rep. 2025 Dec 13;. doi: 10.1038/s41598-025-31499-9. [Epub ahead of print] PubMed PMID: 41390349.
2. Navaeiseddighi Z, Wang Z, Guo K, Hasan S, Schmit T, Ahsan J, Mathur R, Hur J, Khan N. NF-κB driven inflammation mediates loss of upper airway epithelial tolerance to Streptococcus pneumoniae during influenza co-infection. bioRxiv. 2025 Oct 26;. doi: 10.1101/2025.10.25.684585. PubMed PMID: 41279507; PubMed Central PMCID: PMC12633256.
3. Wang Z, Schmit T, Guo K, Tripathi JK, Navaeiseddighi Z, Tyagi A, Mathur R, Hur J, Jurivich D, Khan N. Loss of pulmonary tissue protection and neutrophil microbicidal defects promote severe Aspergillus fumigatus infection during influenza A virus infection. Infect Immun. 2025 Sep 9;93(9):e0023425. doi: 10.1128/iai.00234-25. Epub 2025 Aug 11. PubMed PMID: 40788118; PubMed Central PMCID: PMC12418741.
4. Kong D, He H, Lechner J, Yang J, Zhang A, Li L, Mathur R, Darland DC, Takaku M, Lu L, Peng J, Yang K, Wang X. Spatial profiling of chromatin accessibility reveals alteration of glial cells in Alzheimer’s disease mouse brain. bioRxiv. 2025 May 1. doi: 10.1101/2025.05.01.651759. 
5. Li L, Wu Z, Guarracino A, Villani F, Kong D, Mancieri A, Zhang A, Saba L, Chen H, Brozka H, Vales K, Senko AN, Kempermann G, Stuchlik A, Pravenec M, Lechner J, Prins P, Mathur R, Lu L, Yang K, Peng J, Williams RW, Wang X. Genetic modulation of protein expression in rat brain. iScience. 2025 Feb 21;28(3):112079. doi: 10.1016/j.isci.2025.112079. Epub 2025 Mar 21. PMID: 40124499.
6. Gill JS, Bansal , Guo K, Huang F, Singh H, Hur J, Khan N, Mathur R*. Mitochondrial oxidative stress regulates FOXP3+ T cell activity and CD4-mediated inflammation in frail older adults. International Journal of Molecular Sciences. 2024, 25(11), 6235; https://doi.org/10.3390/ijms25116235
7. Wang Z, Gao P, Guo K, Schirrick G, Gill JS, Weis J, Lund Da Costa A, Rahman M, Mehta H, Fleecs J, Jain S, Debnath T, Hur J, Khan N, Sticca R, Brown-Borg HM, Jurivich DA, Mathur R*. Age-related dysregulation of intestinal epithelium fucosylation is linked to an increased risk of colon cancer. JCI Insight. 2024 Mar 8;9(5). doi: 10.1172/jci.insight.167676. PubMed PMID: 38456503; PubMed Central PMCID: PMC10972600.
8. Guo K, Yombo DJK, Wang Z, Navaeiseddighi Z, Xu J, Schmit T, Ahamad N, Tripathi J, De Kumar B, Mathur R, Hur J, Sun J, Olszewski MA, Khan N. The chemokine receptor CXCR3 promotes CD8(+) T cell-dependent lung pathology during influenza pathogenesis. Sci Adv. 2024 Jan 5;10(1):eadj1120. doi: 10.1126/sciadv.adj1120. Epub 2024 Jan 3. PubMed PMID: 38170765; PubMed Central PMCID: PMC10776024.
9. Huang H, Even Z, Wang Z, Li L, Erickson A, Golovko M, Golovko S, Darland D, Mathur R*, Wang X*. Proteomics Profiling Reveals Regulation of Immune Response to Salmonella enterica Serovar Typhimurium Infection in Mice. Infection and Immunity. 2023;91(1):e00499-22.
10. Chetna Soni, Antariksh Tyagi, Xusheng Wang, and Ramkumar Mathur*. Editorial: The Molecular Basis of Programmed Cell Death and Neuroinflammation in Neurodegenerative Diseases Frontier in Immunology DOI: 10.3389/fimmu.2023.1359136. 2024.
11. Mathur R*, Alam MM, Zhao X-F, Huang Y, Zhu X. Mechanistic insight into the development of TNBS-mediated intestinal fibrosis and evaluating the inhibitory effects of rapamycin. JoVE (Journal of Visualized Experiments). 2019(151):e60067.
12. Mathur R*, Alam MM, Zhao X-F, Liao Y, Shen J, Morgan S, Huang T, Lee H, Lee E, Huang Y. Induction of autophagy in Cx3cr1+ mononuclear cells limits IL-23/IL-22 axis-mediated intestinal fibrosis. Mucosal immunology. 2019;12(3):612-23.
13. Jain S, Abrham E, Khan MN, and Ramkumar Mathur*. An Account of Immune Senescence in the Clinical Pathophysiology of COVID-19 Infection in Aging. Aging and Disease. 2021 Apr;12(2):662-670. doi: 10.14336/AD.2020.1019. e-Collection 2021 Apr. Invited Commentary: Lund Da Costa A, Mehta H, Mathur R*. Promoting autophagy to mitigate coronavirus disease pathology in the elderly. Clinical and Translational Discovery. 2022;2(2):e68.
14. Fleecs J, Abrham E, Kuntz M, Khan MN, Mathur R*. Targeting Pathogenic Inflammation for Therapeutic Intervention Against Colon Cancer. Colon Cancer Diagnosis and Therapy Vol 3: Springer International Publishing Cham; 2022. p. 173-91.
15. Mathur R, Murugaiyan G, Khan MN. Cross-Talk Between Inflammation and Barrier Framework at Mucosal Surfaces in the Lung: Implications for Infections and Pathology. Frontiers in Immunology, 2020. p. 598533.
16. Guo K, Yombo DJK, Wang Z, Navaeiseddighi Z, Xu J, Schmit T, Ahamad N, Tripathi J, De Kumar B, Mathur R, Hur J, Sun J, Olszewski MA, Khan N. The chemokine receptor CXCR3 promotes CD8(+) T cell-dependent lung pathology during influenza pathogenesis. Science Advances. 2024 Jan 5;10(1):eadj1120. doi: 10.1126/sciadv.adj1120. Epub 2024 Jan 3. PubMed PMID: 38170765.
17. Navaeiseddighi Z, Tripathi JK, Guo K, Wang Z, Schmit T, Brooks DR, Allen RA, Hur J, Mathur R, Jurivich D, Khan N. IL-17RA promotes pathologic epithelial inflammation in a mouse model of upper respiratory influenza infection. PLoS Pathogens. 2023 Dec;19(12):e1011847. doi: 10.1371/journal.ppat.1011847. eCollection 2023 Dec. PubMed PMID: 38060620; PubMed Central PMCID: PMC10729944.
18. Schmit T, Guo K, Tripathi JK, Wang Z, McGregor B, Klomp M, Ambigapathy G, Mathur R, Hur J, Pichichero M. Interferon-? promotes monocyte-mediated lung injury during influenza infection. Cell reports. 2022;38(9):110456.
19. Guo K, Yombo DJK, Schmit T, Wang Z, Navaeiseddighi Z, Sathish V, Mathur R, Wu M, Kumar BD, Hur J. Cellular Heterogeneity and Molecular Reprogramming of the Host Response during Influenza Acute Lung Injury. Journal of Virology. 2022;96(21):e01246-22.2021;12(2):662.
20. Even Z, Huang H, Mathur R, Wang X. Genome-Wide Analysis of Methylome in the Mouse Brain using Long-Read Sequencing Technology2021.
21. Alam MM, Zhao X-F, Liao Y, Mathur R, McCallum SE, Mazurkiewicz JE, Adamo MA, Feustel P, Belin S, Poitelon Y. Deficiency of microglial autophagy increases the density of oligodendrocytes and susceptibility to severe forms of seizures. Eneuro. 2021;8(1).
22. Zhao X-F, Liao Y, Alam MM, Mathur R, Feustel P, Mazurkiewicz JE, Adamo MA, Zhu XC, Huang Y. Microglial mTOR is neuronal protective and antiepileptogenic in the pilocarpine model of temporal lobe epilepsy. Journal of Neuroscience. 2020;40(40):7593-608.
23. Schmit T, Ghosh S, Mathur RK, Barnhardt T, Ambigapathy G, Wu M, Combs C, Khan MN. IL-6 deficiency exacerbates allergic asthma and abrogates the protective effect of allergic inflammation against Streptococcus pneumoniae pathogenesis. The Journal of Immunology. 2020;205(2):469-79.
24. Schmit T, Ambigapathy G, Ghosh S, Mathur R, Wu M, Combs C, Khan N. IL-6 deficiency exacerbates allergic asthma and promotes Streptococcus pneumoniae pathogenesis. The Journal of Immunology. 2020;204(1_Supplement):65.8-.8.
25. Debnath T, Kim E-K, Lee K-G, Debnath NC, Mathur R*. Antioxidant compounds from marine seaweeds and their mechanism of action. Journal of Marine Research. 2020;78(2):131-48.
26. Zhao X-F, Alam MM, Liao Y, Huang T, Mathur R, Zhu X, Huang Y. Targeting microglia using Cx3cr1-Cre lines: revisiting the specificity. eneuro. 2019;6(4).
27. Mathur R, Huang T, Alam MM, Zhao X-F, Lee HJ, Lee E, Huang Y, Xinjun Z. 863–Induction of Autophagy in Cx3Cr1+ Mononuclear Cells Limits Il-23/Il22 Axis-Mediated Intestinal Fibrosis. Gastroenterology. 2019;156(6):S-192.
28. Ambigapathy G, Schmit T, Mathur RK, Nookala S, Bahri S, Pirofski L-a, Khan MN. Double-edged role of interleukin 17A in Streptococcus pneumoniae pathogenesis during influenza virus coinfection. The Journal of infectious diseases. 2019;220(5):902-12.
29. Zhao X, Liao Y, Morgan S, Mathur R, Feustel P, Mazurkiewicz J, Qian J, Chang J, Mathern GW, Adamo MA. Noninflammatory changes of microglia are sufficient to cause epilepsy. Cell reports. 2018;22(8):2080-93.
30. Mathur R, Huang Y, Zhu XC. P077 MTOR-MEDIATED SUPPRESSION OF AUTOPHAGY ACTIVITY IN CX3CR1+ MONONUCLEAR PHAGOCYTES CONTRIBUTES TO INTESTINAL FIBROSIS. Gastroenterology. 2018;154(1):S39-S40.
31. Ramkumar Mathur YL, Xiaofeng Zhao, Yunfei Hunag, Xinjun Zhu. IL23/MTOR Axis in CX3CR1 Residential Macrophages Modulates IL22-Mediated Intestinal Fibrosis. Gastroenterology. 2017;152(Issue 5):S612.
32. Ballesté-Delpierre C, Fabrega A, Ferrer-Navarro M, Mathur R, Ghosh S, Vila J. Attenuation of in vitro host–pathogen interactions in quinolone-resistant Salmonella Typhi mutants. Journal of Antimicrobial Chemotherapy. 2016;71(1):111-22.
33. Khan TH, Srivastava N, Srivastava A, Sareen A, Mathur RK, Chande AG, Musti KV, Roy S, Mukhopadhyaya R, Saha B. SHP-1 plays a crucial role in CD40 signaling reciprocity. The Journal of Immunology. 2014;193(7):3644-53.
34. Koblansky AA, Jankovic D, Oh H, Hieny S, Sungnak W, Mathur R, Hayden MS, Akira S, Sher A, Ghosh S. Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii. Immunity. 2013;38(1):119-30.
35. Mathur R, Oh H, Zhang D, Park S-G, Seo J, Koblansky A, Hayden MS, Ghosh S. A mouse model of Salmonella typhi infection. Cell. 2012;151(3):590-602.
36. Kulshreshtha M, Mathur R, Kulshreshtha M, Mathur R. Hindi language and its dialects. Dialect Accent Features for Establishing Speaker Identity: A Case Study. 2012:15-20.
37. Kulshreshtha M, Mathur R, Kulshreshtha M, Mathur R. Speech Materials and Instrumentation. Dialect Accent Features for Establishing Speaker Identity: A Case Study. 2012:21-6.
38. Kulshreshtha M, Mathur R, Kulshreshtha M, Mathur R. Analysis and Results. Dialect Accent Features for Establishing Speaker Identity: A Case Study. 2012:27-50.
39. Krishnareddy S, Mathur R, Wang Z-Y, Arguelles-Grande C, Bhagat G, Green PH, Ghosh S. Sa1338 Characterization of IL-17 Producing Cells in Celiac Disease. Gastroenterology. 2012;5(142):S-276.
40. Krishnareddy S, Mathur R, Bhagat G, Green PH, Ghosh S. Sa1337 Analysis of Toll-Like Receptor and Defensin Expression in Celiac Disease. Gastroenterology. 2012;5(142):S-276.
41. Park S-G, Mathur R, Long M, Hosh N, Hao L, Hayden MS, Ghosh S. T regulatory cells maintain intestinal homeostasis by suppressing ?? T cells. Immunity. 2010;33(5):791-803.
42. Mathur RK, Awasthi A, Saha B. The conundrum of CD40 function: host protection or disease promotion? Trends in parasitology. 2006;22(3):117-22.
43. Majumder N, Dey R, Mathur RK, Datta S, Maitra M, Ghosh S, Saha B, Majumdar S. An unusual pro-inflammatory role of interleukin-10 induced by arabinosylated lipoarabinomannan in murine peritoneal macrophages. Glycoconjugate journal. 2006;23:675-86.
44. Mathur RK, Awasthi A, Saha B, Welburn SC, Coleman PG, Maudlin I. FORMERLY PARASITOLOGY TODAY. Parasitology. 2006;22(3):97-142.
45. Mathur RK, Awasthi A, Wadhone P, Ramanamurthy B, Saha B. Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses. Nature medicine. 2004;10(5):540-4.
46. Awasthi A, Mathur RK, Saha B. Immune response to Leishmania infection. Indian Journal of Medical Research. 2004;119:238-58.
47. Awasthi A, Mathur R, Khan A, Joshi BN, Jain N, Sawant S, Boppana R, Mitra D, Saha B. Brief Definitive Reports-CD40 signaling is impaired in L. major-infected macrophages and is rescued by a p38MAPK activator establishing a host-protective memory T cell response. Journal of Experimental Medicine. 2003;197(8):1037-44. 

Crohn's And Colitis Foundation of America, 2016-2019 

HOST PATHOGEN COBRE PILOT Grant

DaCCOTA (Dakota Cancer Collaborative on Translational Activity) Feasibility Pilot grant

Ph.D.                                      National Center for Cell Science, Pune University, Pune, India

Postdoc                                  Yale University, New Haven, Connecticut, USA

Associate Research Scientist    Columbia University, New York, USA

The primary areas of research in my laboratory are aging, colon cancer, and neurodegenerative disorders. My long-term goal is to define age-associated molecular mechanisms that regulate inflammation and immune dysfunction and to determine how these pathways contribute to the pathogenesis of colorectal cancer and neuroinflammation during aging.

Over the course of my independent and collaborative research program, my laboratory has developed and applied a broad range of experimental approaches, including the generation of conditional knockout mouse models and aging-relevant murine systems. We integrate advanced spatial and single-cell technologies—such as GeoMX digital spatial profiling, single-cell RNA sequencing, chromatin accessibility profiling, and proteomics—with functional immunology and metabolic analyses to interrogate tissue-specific immune–epithelial interactions in the aging colon and brain.

Our work has identified age-dependent dysregulation of epithelial glycosylation, mitochondrial function, autophagy, and immune regulatory pathways that shape the tumor microenvironment in colorectal cancer and influence neuroinflammatory processes linked to neurodegenerative disease. By combining systems-level analyses with mechanistic validation in vivo, we aim to uncover therapeutic targets that can be leveraged to modulate inflammation and immune aging, ultimately improving disease outcomes in both younger and older adults.